In sports, there are winners and losers. And then there are big winners and even bigger losers. Let's check out the odds for which MLB team will have the best record in baseball and who will have the fewest, at DraftKings Sportsbook as of May 7. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports. Most MLB regular-season wins Dodgers: -105 (bet $10 to win $19.52 total)Yankees: +310 (bet $10 to win $41 total)Cubs: +390 (bet $10 to win $5549total)Braves: +450 (bet $10 to win $55 total)Rays: +1600 (bet $10 to win $170 total)Mariners: +3500 (bet $10 to win $360 total)Padres: +4000 (bet $10 to win $410 total)Phillies: +4500 (bet $10 to win $460 total) What to know: Of course, the Dodgers are favored to win the most games during the regular season, and they are also favored to win the World Series for the third straight year. As of May 7, the Dodgers are first in the AL West, and have the fifth-most wins in baseball (23). The current wins leaders are the Braves (26), Yankees (25) and Cubs (25). The Brewers led MLB in wins last season with 97, preceded by the Dodgers in 2024 (98), the Braves in 2023 (104), the Dodgers in 2022 (111), the Giants in 2021 (107) and the Dodgers in the COVID-shortened 2020 season (43). Dating back to 2013, L.A. has won at least 90 games every season (outside of the COVID year). Fewest MLB regular-season wins Rockies: -155 (bet $10 to win $16.45 total)White Sox: +450 (bet $10 to win $55 total)Nationals: +500 (bet $10 to win $60 total)Angels: +650 (bet $10 to win $75 total)Marlins: +1400 (bet $10 to win $150 total)Twins: +2500 (bet $10 to win $260 total)Giants: +2800 (bet $10 to win $290 total)Astros: +5000 (bet $10 to win $510 total) What to know: The Rockies are tied for the fewest wins in baseball as of May 7 (14). Last season, they had the fewest wins in baseball with 43, 17 fewer than the closest team the White Sox, with 60. In 2024, Colorado had the second-fewest wins (61) and the third-fewest in 2023 (59).