At times, especially early, the Colorado Avalanche looked disjointed on defense. One player's absence made that big of difference.With star defenseman Cale Makar sidelined by an upper-body injury, the Avalanche hardly resembled the top-seeded team that rolled through the first two rounds. They experimented with different line combinations in a 4-2 loss to the Vegas Golden Knights on Wednesday night in Game 1 of the Western Conference Final. "Theres definitely a trickle-down effect to that, Avalanche coach Jared Bednar said of not having Makar. But hes not playing. We have find a way.A few breakdowns led to some big plays. One of the biggest was Dylan Coghlan splitting the defense down the middle and scoring through the pads of goaltender Scott Wedgewood. Just the way the night went as the Avalanche trailed 3-0 before making it a one-goal game with 2:21 remaining on a power-play tally from captain Gabriel Landeskog.They capitalized early, we fought back," said Wedgewood, who stopped 24 shots. But just unfortunately didnt have enough.Colorado relied heavily on Devon Toews, who logged 27 minutes, 32 seconds. Brett Kulak was just over 23 minutes and Sam Malinski at 20:31. Josh Manson was just over 19 minutes, Brent Burns, at 41 years old, just shy of 17 minutes and Jack Ahcan, the defenseman who filled in for Makar, was limited to 7:34.I think the guys that we had playing tonight, not just the D, were capable more and capable of better, Bednar said. It just wasnt there for us tonight.The availability of Makar for Game 2 on Friday night remains unknown. Although, Bednar did say that Makar was doing a lot better," on Wednesday after morning skate. Makar hasn't been practicing with the team since he left the ice holding his right arm following a collision late in Game 5 against Minnesota last Wednesday. He did return in that game as Colorado won in overtime. Makar also briefly left Game 1 after taking a hit along the boards, with his right leg flying into the air before he fell to the ice.His absence is a blow for the Avalanche. This was the first time Makar has missed a playoff game for the Avalanche with an injury. He was suspended one game for interference during a series against Seattle in 2023.The Norris Trophy finalist has four goals and an assist while averaging nearly 25 minutes of ice time through the opening two rounds. Makar also is an integral part of Colorado's special teams.Best defenseman in the world, Avalanche forward Logan OConnor said before Game 1. "Hes not going to be easily replaced. Theres not one guy thats going to be able to do it. I think the advantage we have with the group we have in the game tonight is a lot of guys can be minute-munchers for us.Cale presents a dynamic ability that is super-unique in the league. No ones going to replicate that tonight, but its on the D-core as a whole, and our group as a whole, to try and pick it up when we can.___AP NHL: https://apnews.com/hub/stanley-cup and https://apnews.com/hub/nhl