The Arizona Cardinals will face 14 different opponents in the 2026 regular season. They will face the San Francisco 49ers twice, as they do every year, being division rivals. They play them early in Week 3 on the road and then close out the season at home in Week 18. In the newest podcast episode, continuing with the opponent preview series, I was joined by Niners Wire lead writer Kyle Madson to chat about the 49ers. We talked about the crazy 2025 season in which the 49ers made the playoffs and won a playoff game despite surviving scores of injuries. We go into the departure of Robert Saleh to go be a head coach again and the addition of new defensive coordinator Raheem Morris, and then discuss their work in free agency and the draft. Then, Madson tells me what sort of expectations the 49ers have in 2026. (1:00) The 49ers' 2025 season(10:35) Offseason coordinator changes, free agency and the draft(28:33) Expectations for 2026Enjoy the show!Enjoy the show with the embedded player above or by subscribing to the show onApple Podcasts, Spotify,YouTubeor your favorite podcast platform, so you never miss a show. Make sure as well to give it a five-star rating!This article originally appeared on Cards Wire: Arizona Cardinals 2026 opponent preview: San Francisco 49ers offseason